Why Tapentadol 200mg Causes Less Respiratory Depression
Tapentadol 200 mg is known to cause less respiratory depression compared to traditional opioids like morphine. This is due to its dual mechanism of action—combining mu-opioid receptor agonism with norepinephrine reuptake inhibition (NRI). Because it relies less on pure opioid activity, Tapentadol exerts a reduced depressive effect on the brain's respiratory centers, especially at equivalent pain-relief doses. This makes it a safer alternative for opioid-tolerant patients, though monitoring is still essential.
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